Gary L. Westbrook

This study shows that loss of hilar mossy cells alters dentate gyrus structure and function, but the circuit remains functionally resilient.

This study develops a mouse model of anti-AMPAR encephalitis and shows that autoreactive B cells and plasma cells accumulate in the brain, driving disease progression.

The paper shows that exercise preferentially activates dentate granule cells via inputs from the lateral entorhinal cortex, not through dendritic molecular changes.

This study investigates how mossy cells in the hippocampus reorganize their connectivity and function after status epilepticus, showing increased inhibitory effects despite reduced excitation.

This study shows that α2δ-2 is essential for coupling calcium entry to two postsynaptic signals in Purkinje cells.

This study examines the role of α2δ-2 protein in cerebellar climbing fiber synapses using Cacna2d2 knockout mice, revealing structural and functional changes in synaptic transmission and their impact on ataxia.

Exercise increases hippocampal synaptic function through activity-dependent expression of Mtss1L, a BAR protein that promotes dendritic spine formation.

The paper shows that sprouted mossy fibers in temporal lobe epilepsy can initiate recurrent network activity despite short-term depression due to high initial glutamate release and lack of adenosine inhibition.

This study develops an active immunization model in mice that mimics anti-NMDA receptor encephalitis, revealing neuroinflammation and immune cell involvement in disease pathogenesis.

The paper shows that newly integrated granule cells in the hippocampus preferentially receive inputs from the lateral entorhinal cortex, which is important for pattern separation.

The paper investigates how mitral and external tufted cells in the olfactory bulb process high-frequency afferent input, finding that their distinct temporal response profiles arise from differences in dendrodendritic circuitry rather than presynaptic factors.