Assigning functionality to cysteines by base editing of cancer dependency genes
Haoxin Li, Tiantai Ma, Jarrett R. Remsberg, Sang Joon Won, Kristen E. DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin Tianmeng Zhao, Tony P. Huang, Bingwen Lu, Gabriel M. Simon, Bruno N. Melillo, Stuart L. Schreiber, Jens Lykke‐Andersen, David R. Liu, Benjamin F. Cravatt
The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.
Nature Chemical Biology · Oct 2, 2023Peer-reviewedSystems Biology