BiochemistrybioRxivPreprint
Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels
Elva Ye, Alberto Russo, Roberta Castelli…·Benjamin F. Cravatt
DOI 10.64898/2026.08.25.747126
Author
Gabriel M. Simon
Vividion Therapeutics (United States)ORCID 0009-0000-9403-7178Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 26 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- BiochemistryJournal of the American Chemical SocietyPeer-reviewed
A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP
Yijun Xiong, Christopher J. Reinhardt, Tracey Nguyen…·Benjamin F. Cravatt
The paper compares acrylamide and butynamide stereoprobes to identify covalent inhibitors of the actin maturation protease ACTMAP in human cancer cells.
2 citations - ImmunologyACS Infectious DiseasesPeer-reviewed
Cysteine reactivity profiling identifies host regulators of Mycobacterium tuberculosis replication in human macrophages
John K. Neff, Kristen E. DeMeester, Paola K. Párraga Solórzano…·Michael U. Shiloh
The paper identifies host proteins regulating Mycobacterium tuberculosis replication in macrophages using cysteine reactivity profiling and genetic perturbation.
2 citationstop 3% - BiochemistryNature Chemical BiologyPeer-reviewed
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5
F. Wieland Goetzke, Steffen M. Bernard, Cheng‐Wei Ju…·Benjamin F. Cravatt
The paper develops covalent ligands that specifically target a complexoform of TRMT112, revealing partner-specific functional effects through allosteric activation of METTL5.
7 citationstop 2% - Cancer BiologySciencePeer-reviewed
Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
Joseph E. Klebba, Nilotpal Roy, Steffen M. Bernard…·Matthew P. Patricelli
The paper develops covalent inhibitors targeting the RAS binding domain of PI3Kα, showing efficacy against RAS and HER2-driven tumors without affecting glucose homeostasis.
16 citationstop 4% - Systems BiologyNature Chemical BiologyPeer-reviewed
Assigning functionality to cysteines by base editing of cancer dependency genes
Haoxin Li, Tiantai Ma, Jarrett R. Remsberg…·Benjamin F. Cravatt
The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.
62 citationstop 2% - Developmental BiologybioRxivPreprint
ABHD4-dependent developmental anoikis protects the prenatal brain from pathological insults
Zsófia I. László, Zsolt Lele, Miklós Zöldi…·István Katona
The paper identifies ABHD4 as a mediator of developmental anoikis that protects the prenatal brain from pathological insults by eliminating abnormally detached progenitor cells.
DOI 10.1101/2019.12.17.879551