Qing Chen

This study identifies PRMT1-SFPQ as a regulator of intron retention in craniofacial development, leading to reduced matrix gene expression through NMD.

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

This study shows that β-glucan-induced trained immunity in mice enhances antibody levels after vaccination by improving antigen presentation and T-cell responses.

The paper identifies a small molecule, A1155463, that induces trained immunity in macrophages without being immunogenic, enhancing anti-tumor resistance in mice.