Nicolas G. Hartel

This paper describes a method to simultaneously profile the transcriptome and proteome from single cells, showing moderate correlation between the two modalities.

The paper uses LC-MS proteomics to identify PRMT-1 substrates and quantify proteome changes in C. elegans prmt-1 and prmt-5 knockout mutants.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

The paper identifies a proteomic signature of senescence in primary human mammary epithelial cells using mass spectrometry-based proteomics and integrates it with transcriptomic data.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

The paper develops a combined chemical and immunoaffinity approach to profile protein methylation, identifying novel PRMT1 targets and revealing dynamic interactions between methyltransferases.