Manuel Sánchez-Alavez

This paper identifies atypical tetracyclines that promote longevity and neuroprotection by inhibiting cytosolic translation, independent of classical mechanisms and antibiotic activity.

Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).

The paper identifies Emerin as an activity-induced protein that gates neuronal plasticity by inhibiting protein synthesis and altering dendritic spine morphology.