Karl F. Gruber

Triacylglycerol fatty acid composition modulates ATGL regioselectivity and diacylglycerol output

This study shows that ATGL's regioselectivity in cleaving triacylglycerol depends on fatty acid chain length and composition, leading to specific diacylglycerol regioisomers.

CLN6 is a glycerophosphoglycerol epimerase in bis(monoacylglycero)phosphate biosynthesis

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

Acid phospholipase A1 promotes lysosomal membrane catabolism

This study identifies acid phospholipase A1's role in lysosomal glycerophospholipid catabolism and shows its interaction with bis(monoacylglycero)phosphate and inhibition by cationic amphiphilic drugs.

Flattening the curve - How to get better results with small deep-mutational-scanning datasets

This paper improves prediction performance on small DMS datasets by using structural representations and data augmentation, achieving results comparable to sequence-based methods on large datasets.

SARS-CoV-2 Entry Protein TMPRSS2 and Its Homologue, TMPRSS4 Adopts Structural Fold Similar to Blood Coagulation and Complement Pathway Related Proteins

This study analyzes the amino acid sequences and predicted 3D structures of TMPRSS2 and TMPRSS4, revealing structural similarities to blood coagulation proteins and suggesting potential therapeutic targets for COVID-19.