Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity
David J. Peeler, Ziyin Wang, Livia Spiga, Simbarashe Jokonya, Thomas Chubicka, Daniel Reumann, Katsiaryna Shramko, Laia Rigat Nogareda, Paul F. McKay, Dinh Chuong Nguyen, Marco Antonio Briones-Orta, Patrick S. Stayton, Molly M. Stevens, Robin J. Shattock, John S. Tregoning
This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.
bioRxiv · Sep 18, 2026 · PreprintImmunology