Jonathan E. Dworkin

Mechanistic insights into E. coli recovery from growth arrest

This study investigates how E. coli recovers from growth arrest by analyzing the role of RimM in ribosome maturation and recovery mechanisms.

Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter

This paper develops a dynamic luminescent reporter to measure (p)ppGpp levels in Bacillus subtilis, revealing its role in gene regulation and metabolic responses to nutrient limitation.

(p)ppGpp-dependent activation of gene expression during nutrient limitation

This study identifies a mechanism in Bacillus subtilis where (p)ppGpp links reduced protein synthesis during nutrient limitation to the activation of specific genes like hpf, facilitating survival and developmental responses.

Simultaneous measurements of translation rate and transcriptome in single bacterial cells by scTR-seq uncovers linked regulation within a specialized active cell population.

The paper measures translation rates and transcriptomes in single bacterial cells to identify a subpopulation with increased protein translation and specific gene overexpression under nutrient limitation.

Multisite phosphorylation regulates phenotypic variability in antibiotic tolerance

This study shows that multisite phosphorylation regulates phenotypic variability in antibiotic tolerance by controlling the distribution of sasA expression in bacterial populations.