Author

Christian Luca Flugel

Charité – Universitätsmedizin BerlinORCID 0000-0002-8212-9996Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ana-Maria NitulescuiD· 1 shared Carla Fuster‐GarcíaiD· 1 shared Dimitrios L. WagneriD· 1 shared Geoffroy AndrieuxiD· 1 shared Hans‐Dieter VolkiD· 1 shared Isabell KassingiD· 1 shared Jonas KathiD· 1 shared Laura Marie HartmanniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Ana-Maria NitulescuORCID

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1 paper

Recent·Most cited

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations

Viktor Glaser, Lily Jo Becker, Carla Fuster‐García, Luis Huth, Ana-Maria Nitulescu, Yaolin Pu, Isabell Kassing, Laura Marie Hartmann, Christian Luca Flugel, Roberts Kārkliņš, Shona Maria Shaji, Marie Pouzolles, Maik Stein, Geoffroy Andrieux, Toni Cathomen, , Dimitrios L. Wagner

This paper develops BEKI, a base editor-based method for targeted transgene insertion and multiplex gene disruption in T cells, reducing chromosomal translocations compared to Cas9-based approaches.

bioRxiv · Sep 15, 2025 · PreprintSynthetic Biology