Magdalena Zielonka

Glial subcellular specialisation resolved with high resolution spatial transcriptomics

The paper develops a spatial averaging framework to analyze glial subcellular specialization in spatial transcriptomics data from mouse and human brain tissue, revealing differential transcriptomic responses between glial soma and processes in health and disease.

The Alzheimer's disease neurodegenerative cascade reconstructed in human L2/3 excitatory neurons

The paper reconstructs the Alzheimer's disease neurodegenerative cascade in human L2/3 excitatory neurons using single-nucleus RNA sequencing data from multiple datasets.

The Alzheimer's therapeutic Lecanemab induces an amyloid-clearing program in microglia

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

Applying high-resolution spatial transcriptomics to characterise the amyloid plaque cell niche in Alzheimer's Disease

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.