Author

Sierra T. Wright

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Elizabeth HeadiD· 4 shared Justine A. SilvaiD· 2 shared William H. YongiD· 2 shared Adolfo SequeiraiD· 1 shared Alexis De La Rosa· 1 shared Amanda Wilson· 1 shared Anna Virovka· 1 shared Ashley Renfro· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Elizabeth HeadORCID

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Author profile →

4 papers

Recent·Most cited

Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome associated Alzheimer disease

Chuhanwen Sun, Raina W. Thomas, Cherie A Stringer, Kyriaki Galani, Li‐Lun Ho, Na Sun, Ashley Renfro, Sierra T. Wright, Rosalind Mott Firenze, Li‐Huei Tsai, Elizabeth Head, M Kellis, Jiekun Yang

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

bioRxiv · Apr 21, 2026 · PreprintBioinformatics

UC Irvine Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human Brain Cell Atlas Project

Jillian V. Berry, Bryan M Tran, Ginny Wu, Zhiqun Tan, Elizabeth Mendoza, Miyoung Kim, Zeynep Arat, Payton Sho Huai Lin, Lorena Valenzuela, Todd C. Holmes, Anna Virovka, Melina Thaxton, Matthew Nguyen, Sabrina Stein, Victoria Raha Sigaroudi, , Xiangmin Xu

The paper describes a multi-institutional program for collecting neurotypical human brains to support multiomic brain cell atlas studies, highlighting challenges and opportunities for donor recruitment.

bioRxiv · Dec 26, 2025 · PreprintNeuroscience

Myo-inositol and total NAA in the hippocampus are linked to CSF tau pathology in cognitively normal older adults

Jessica N Lingad, Casey R. Vanderlip, Sierra T. Wright, Lorena Sordo, Elizabeth Head, Craig E.L. Stark

The paper links hippocampal myo-inositol and total NAA levels to CSF tau pathology in cognitively normal older adults using 1H-MRS.

Neurobiology of Aging · Oct 30, 2025Peer-reviewedNeuroscience

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience