Sammy Weiser Novak

QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data

QuantEM provides a vision transformer-based platform for EM data segmentation and analysis, achieving accurate zero-shot segmentation with less data than existing models.

In situ Proteomics Unveils Specialized Domains for Extrasynaptic Signaling on Neuronal Cilia

The paper uses in situ proteomics to show neuronal cilia have specialized nanodomains for extrasynaptic signaling, enriched in synaptic proteins and neurotransmitter receptors.

Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

Astrocyte glypican 5 regulates synapse maturation and stabilization

This study shows astrocyte glypican 5 is necessary for synapse maturation and stabilization in the developing mouse cortex, with implications for neurological disorders.

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

Oligodendrocyte calcium signaling sculpts myelin sheath morphology

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

This study identifies age-related synapse loss and violation of the ultrastructural size principle in the marmoset dlPFC as factors underlying working memory impairment in aged individuals.

Deep Learning-Based Point-Scanning Super-Resolution Imaging

This paper introduces a deep learning method to enhance the resolution and speed of point-scanning imaging systems by restoring undersampled images.

Endosomal Sorting Drives the Formation of Mutant Prion Endoggresomes

The paper identifies endosomal sorting pathways that drive the formation of mutant prion endoggresomes and shows that inhibiting this process can reduce axonal dysfunction.