Kristen M. Harris

This study generates Synpo KO rats to investigate Synpo's role in synaptic plasticity, development, and behavior, finding reduced LTP and body stature effects.

This paper introduces a curvature-based machine learning method for automated segmentation of dendritic spines in 3D EM images, showing improved analysis of spine morphology in complex neural networks.

The paper investigates how presynaptic vesicle density changes during LTP and links it to axonal bouton enlargement.

The paper uses spatial transcriptomics to analyze cardiomyocyte states in pressure-overloaded mouse hearts, finding pro-fibrotic states linked to microenvironmental changes.

This study investigates how perisynaptic astroglia interact with synapses during long-term potentiation and depression in the hippocampal dentate gyrus of rats.

PyReconstruct is a new open-source annotation tool designed for volume electron microscopy, offering improved features for segmentation, curation, and data management across multiple disciplines.

The paper shows that synaptic vesicle clusters become less dense and more dispersed during long-term potentiation, with increased mobility and a transition from compact to loose organization.

This paper introduces a method to generate dense 3D segmentations from sparse 2D annotations, achieving accuracy comparable to dense annotations with significantly reduced human effort.

This study shows that long-term potentiation (LTP) increases synaptic information storage capacity in adult rat hippocampus by expanding the range of synapse sizes and improving precision.

This study identifies age-related synapse loss and violation of the ultrastructural size principle in the marmoset dlPFC as factors underlying working memory impairment in aged individuals.

The paper introduces a method to measure synaptic information storage capacity (SISC) using 3DEM data from rat hippocampus and finds regional and LTP-dependent variations in SISC.

This paper introduces a deep learning method to enhance the resolution and speed of point-scanning imaging systems by restoring undersampled images.

This study examines the developmental timeline of long-term potentiation (LTP) in mouse hippocampus, revealing species differences in the onset and reliability of synaptic plasticity.

The paper describes a method to analyze ultrastructural changes in axons after optogenetic stimulation to induce L-LTP, revealing synapse-specific modifications at the nanoscale.

The paper shows that dendritic SER complexity increases at enlarged synapses during LTP in adult rat hippocampus, supporting enhanced synapse growth.