Uri Manor

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart

The paper uses spatial transcriptomics to analyze cardiomyocyte states in pressure-overloaded mouse hearts, finding pro-fibrotic states linked to microenvironmental changes.

The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

Mitochondrial pull-outs are a distinct type of dynamic tubulation events regulated by mitochondrial activity

The paper identifies mitochondrial pull-outs as a new type of dynamic tubulation regulated by mitochondrial activity and metabolism, enhancing network connectivity and respiratory function.

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

Astrocyte glypican 5 regulates synapse maturation and stabilization

This study shows astrocyte glypican 5 is necessary for synapse maturation and stabilization in the developing mouse cortex, with implications for neurological disorders.

PSSR2: a user-friendly Python package for democratizing deep learning-based point-scanning super-resolution microscopy

PSSR2 provides a user-friendly Python package for applying deep learning-based super-resolution and denoising to undersampled microscopy data without requiring programming expertise.

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

Mfn2 promotes NCLX-mediated Ca2+ release from mitochondria

This study identifies Mfn2's role in promoting NCLX-mediated Ca2+ release from mitochondria, linking mitochondrial ROS to mitophagy via Ca2+ signaling.

INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement

This study shows INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement through high-resolution imaging and genetic manipulation.

VASCilia (Vision Analysis StereoCilia): A Napari Plugin for Deep Learning-Based 3D Analysis of Cochlear Hair Cell Stereocilia Bundles

VASCilia is a Napari plugin that uses deep learning to analyze 3D cochlear hair cell stereocilia bundles, revealing biological insights about actin content and bundle organization.

A general method for bootstrapping dense 3D segmentations from sparse 2D annotations

This paper introduces a method to generate dense 3D segmentations from sparse 2D annotations, achieving accuracy comparable to dense annotations with significantly reduced human effort.

Large-scale annotated dataset for cochlear hair cell detection and classification

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

Altered Fhod3 Expression Involved in Progressive High-Frequency Hearing Loss via Dysregulation of Actin Polymerization Stoichiometry in The Cuticular Plate

This study identifies Fhod3 as a key regulator of actin dynamics in the cuticular plate, linking its dysregulation to progressive high-frequency hearing loss in mice.

Oligodendrocyte calcium signaling sculpts myelin sheath morphology

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

Cochlear transcriptome analysis of an outbred mouse population (CFW)

The paper analyzes the cochlear transcriptome of an outbred mouse population to identify cell-type specific changes associated with age-related hearing loss.

Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

This study identifies age-related synapse loss and violation of the ultrastructural size principle in the marmoset dlPFC as factors underlying working memory impairment in aged individuals.

Local Shape Descriptors for Neuron Segmentation

This paper introduces an auxiliary learning task using Local Shape Descriptors to improve neuron segmentation in electron microscopy volumes, achieving performance comparable to state-of-the-art methods with greater efficiency.

Deep Learning-Based Point-Scanning Super-Resolution Imaging

This paper introduces a deep learning method to enhance the resolution and speed of point-scanning imaging systems by restoring undersampled images.

Endosomal Sorting Drives the Formation of Mutant Prion Endoggresomes

The paper identifies endosomal sorting pathways that drive the formation of mutant prion endoggresomes and shows that inhibiting this process can reduce axonal dysfunction.