Michael B. Fessler

DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

This study shows that DGKα and ζ deficiency in Tregs leads to their dysfunction, conversion to pathogenic Tfh cells, and triggers IgG1-predominant autoimmunity.

Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer

The paper identifies a transitional stage in breast cancer metastasis characterized by malignant epithelial diversification and inflammatory neutrophil remodeling, linking these to poor clinical outcomes.

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

Flotillin-2 dampens T cell antigen-sensitivity and functionality

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.