Raja Jothi

Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer

The paper identifies a transitional stage in breast cancer metastasis characterized by malignant epithelial diversification and inflammatory neutrophil remodeling, linking these to poor clinical outcomes.

Refate identifies chemical compounds to target trans-regulatory networks for cellular conversion

Refate identifies chemical compounds targeting trans-regulatory networks to enable cellular conversion by integrating single-cell data and drug databases.

Systematic evaluation of blastoid models of early human development

This study evaluates blastoid models of early human development by comparing them to a reference map of human blastocysts, identifying their lineage coverage and differentiation progression.

Bivalent chromatin protects reversibly repressed genes from irreversible silencing

The paper shows that bivalent chromatin protects reversibly repressed genes from irreversible silencing by maintaining H3K4me3 at promoters, which prevents de novo DNA methylation in adult cancers.

NF-Y Controls Fidelity of Transcription Initiation at Gene Promoters Through Maintenance of the Nucleosome-Depleted Region

This study shows NF-Y maintains nucleosome-depleted regions at promoters to ensure accurate transcription initiation, preventing aberrant gene expression.

Multi-Omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

The paper maps multi-omic changes during mouse pluripotency transition, showing phosphoproteome dynamics precede epigenome and transcriptome changes.