Satoshi Arai

This paper develops a nanoheater-thermometer to measure subcellular temperature and monitor HSF1 responses in living cells, showing that localized heating induces HSF1 foci at lower temperatures than whole-cell heating.

The paper develops an electroporation method to deliver protein biosensors into differentiated myotubes for real-time metabolic imaging.

OptoChaperone enables reversible, spatiotemporal control of protein condensates using light, demonstrating efficacy in regulating disease-related condensates without chemical additives or genetic modifications.

The paper demonstrates NIR laser-induced release of acetylcholine from VPc-embedded liposomes, causing Ca2+ flux in biospecimens.

The paper develops a universal platform for single fluorescent protein-based FLIM biosensors capable of detecting multiple analytes with a dynamic range of 0.5 to 1.0 ns.