Author

Yongjia Li

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Gabriel MbalavieleiD· 3 shared Khushpreet KauriD· 3 shared Chun WangiD· 2 shared Chun WangiD· 2 shared Deborah V. NovackiD· 2 shared Kunjan KhannaiD· 2 shared Nitin Kumar PokhreliD· 2 shared Saumya BhagatiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Gabriel MbalavieleORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pyroptotic cell-derived factors promote osteoclast differentiation

Yongjia Li, Chun Wang, 许灿新, Wei Zou, Khushpreet Kaur, Ria Rohatgi, Nitin Kumar Pokhrel, Ria Rohatgi, Yousef Abu‐Amer, 许灿新

This study shows that NLRP3CA-induced pyroptosis releases soluble proteins that promote osteoclast differentiation independently of IL-1β.

bioRxiv · Sep 7, 2026 · PreprintCell Biology

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation

Wei Zou, Chun Wang, Yongjia Li, Wentong Jia, Steven L. Teitelbaum, Gabriel Mbalaviele

The paper shows that LPS-induced pyroptosis in bone marrow promotes periosteal bone formation by releasing factors that stimulate osteogenic differentiation of skeletal stem cells.

Journal of Bone and Mineral Research · Dec 17, 2025Peer-reviewedCell Biology

Staphylococcus aureus inhibits the NLRP3 inflammasome in macrophages during the early phases of intracellular infection, but not the late phases

Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor, Chun Wang, Yongjia Li, Gaurav Swarnkar, Kunjan Khanna, James E. Cassat, Deborah V. Novack, Gabriel Mbalaviele

This study shows S. aureus inhibits NLRP3 inflammasome activation in macrophages during early infection but not late infection, reducing bacterial load and pyroptosis.

bioRxiv · Sep 24, 2025 · PreprintImmunology

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx

Khushpreet Kaur, Yael Alippe, Chun Wang, Nicholas P. Semenkovich, Saumya Bhagat, Kunjan Khanna, Yongjia Li, Nitin Kumar Pokhrel, Timothy R. Peterson, Deborah V. Novack, Yousef Abu‐Amer, Roberta Faccio, Gabriel Mbalaviele

The paper shows Tmem178 suppresses NLRP3 inflammasome activation in osteoclasts by limiting calcium release, preventing excessive bone resorption.

bioRxiv · Jul 28, 2025 · PreprintImmunology