Thanh Nguyen

This study identifies IFRD1 as a ribosome-salvaging factor that stabilizes non-translating 80S ribosomes during ER stress, preventing degradation and cell death.

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

This study investigates the effects of ribosome biogenesis inhibition in vivo by deleting Nat10 in mice, revealing p53-dependent and -independent consequences on acinar cell function and tumorigenesis.