Author

Dorthe Helena Larsen

Danish Cancer SocietyORCID 0000-0002-8280-1252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Apoorva BaluapuriiD· 1 shared Barbara TrifaultiD· 1 shared Beatriz Suárez-QuinteroiD· 1 shared Blanca NietoiD· 1 shared Carsten Patrick AdeiD· 1 shared Cintia Checa-RodrígueziD· 1 shared Daniel Gómez-CabelloiD· 1 shared Daniel SolvieiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Apoorva BaluapuriORCID

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2 papers

Recent·Most cited

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts

Barbara Trifault, Victoria Mamontova, Giacomo Cossa, Sabina Ganskih, Yuanjie Wei, Julia Hofstetter, Pranjali Bhandare, Apoorva Baluapuri, Blanca Nieto, Daniel Solvie, Carsten Patrick Ade, Peter Gallant, Elmar Wolf, Dorthe Helena Larsen, Mathias Munschauer, Kaspar Burger

The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.

Nucleic Acids Research · Jan 4, 2024Peer-reviewedMolecular Biology

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instability

Cintia Checa-Rodríguez, Beatriz Suárez-Quintero, Laura Contreras, Lea Milling Korsholm, Dorthe Helena Larsen, Jesús de la Cruz, Jiří Bártek, Daniel Gómez-Cabello

The paper shows RNA polymerase II is essential for repairing rDNA breaks in nucleolar caps, preventing genomic instability and cancer cell death.

bioRxiv · Oct 20, 2023 · PreprintMolecular Biology