Sabina Ganskih

HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels

This study identifies that HIV-2 evades ZAP restriction through adaptations in the U3 LTR region despite having higher CpG levels compared to HIV-1 and SIVsmm.

SHIFTR enables the unbiased and multiplexed identification of proteins bound to specific RNA regions in live cells

SHIFTR identifies proteins bound to specific RNA regions in live cells with high accuracy and low input, enabling comprehensive RNA interactome mapping.

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts

The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts cytomegalovirus

This study shows that ZAP restricts HCMV infection by destabilizing viral transcripts with low CG content, revealing its role in antiviral defense against DNA viruses.