Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems
Vivian S. Park, Lauren E. Pope, Justin P. Ingram, Grace A. Alchemy, Julie J. Purkal, Magdalena B. Murray, Sha Jin, Eli Y. Andino-Frydman, Sanjana Singh, Anlu Chen, Priya Narayanan, Sarah Kongpachith, Darren C. Phillips, Scott J. Dixon, Relja Popovic
This study shows that GPX4 inhibitor sensitivity differs between 2D and 3D cultures due to lipid composition changes, with 3D cultures showing resistance through PUFA displacement by MUFAs.
Cancer Research · Sep 5, 2025Peer-reviewedCancer Biology