Anlu Chen

This study shows that GPX4 inhibitor sensitivity differs between 2D and 3D cultures due to lipid composition changes, with 3D cultures showing resistance through PUFA displacement by MUFAs.

The paper demonstrates multiplex base editing to convert TAG to TAA codons in 33 essential human genes and introduces a computational tool for recoding.

This study uses mouse chromosome substitution strains to identify both additive and epistatic genetic loci influencing complex traits and gene expression.

The paper identifies homozygous mutations in PIK3C2A causing a new Mendelian disorder with short stature, skeletal abnormalities, cataracts, and ciliary dysfunction.

The paper shows that inter-chromosomal epistasis significantly influences glucose homeostasis and gene expression in mice, often overriding additive genetic effects.