Author

Hideyuki Higashi

Brigham and Women's HospitalORCID 0000-0002-8286-8190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

Cassandra L. CliftiD· 2 shared Elena Rabkin AikawaiD· 2 shared Florian SchlotteriD· 2 shared Jochen Daniel MuehlschlegeliD· 2 shared Mandy E. TurneriD· 2 shared Mark C. BlaseriD· 2 shared Masanori AikawaiD· 2 shared Sasha A. SinghiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

Cassandra L. CliftORCID

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2 papers

Recent·Most cited

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis

Cassandra L. Clift, Mark C. Blaser, Francesca Bartoli‐Leonard, Florian Schlotter, Hideyuki Higashi, Shiori Kuraoka, Taku Kasai, Mandy E. Turner, Tan Pham, Katelyn A. Perez, Simon Christopher Robson, Simon C. Body, Jochen Daniel Muehlschlegel, Masanori Aikawa, Sasha A. Singh, Elena Rabkin Aikawa

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

Arteriosclerosis Thrombosis and Vascular Biology · Aug 14, 2025Peer-reviewedPathology

Conserved and Divergent Modulation of Calcification in Atherosclerosis and Aortic Valve Disease by Tissue Extracellular Vesicles

Mark C. Blaser, Fabrizio Buffolo, Arda Halu, Mandy E. Turner, Florian Schlotter, Hideyuki Higashi, Lorena Pantano, Cassandra L. Clift, Louis Saddic, Samantha K. Atkins, Maximillian A. Rogers, Tan Pham, Amélie Vromman, Eugenia Shvartz, Galina K. Sukhova, , Elena Rabkin Aikawa

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.

Circulation · Jul 10, 2023Peer-reviewedSystems Biology