Elena Rabkin Aikawa

This study shows pemafibrate reduces calcific aortic valve disease by modulating macrophage-VIC interactions, independent of lipid lowering.

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

This study uses nanoparticle-enhanced plasma proteomics to identify low-abundant proteins in atherosclerosis-prone mice, revealing disease-related changes in inflammation, lipid metabolism, and potential biomarkers.

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.