Taku Kasai

Platelet-endothelial crosstalk drives distinct endothelial dysfunction in bicuspid aortic valve disease

This study shows that platelet-derived signals cause distinct endothelial dysfunction in bicuspid aortic valve disease, leading to mitochondrial dysfunction and immune cell recruitment.

Multiparametric Extracellular Vesicle Profiling Identifies a Distinct Circulating Signature of Bicuspid Aortic Valve Disease

This study identifies a distinct circulating extracellular vesicle signature in bicuspid aortic valve disease through single-vesicle analysis and proteomic profiling.

Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease

This study shows pemafibrate reduces calcific aortic valve disease by modulating macrophage-VIC interactions, independent of lipid lowering.

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model

This study uses nanoparticle-enhanced plasma proteomics to identify low-abundant proteins in atherosclerosis-prone mice, revealing disease-related changes in inflammation, lipid metabolism, and potential biomarkers.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.