Simon Christopher Robson

This study shows CD39 prevents necrotic lung lesions in tuberculosis by inhibiting P2RX7-mediated macrophage death and inflammation.

This paper shows that targeting CD39 on endothelial cells prevents toxin-induced pulmonary hypertension in mice by multiple mechanisms including adenosine signaling and reducing inflammation.

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

This study investigates the role of adiponectin signaling in urinary bladder function, finding that its absence leads to altered bladder smooth muscle contractility and purinergic pathway changes.

This study shows microglia regulate cerebral blood flow through CD39-mediated ATP breakdown, affecting neurovascular coupling and CBF reactivity.

This paper develops an endothelial-targeted CD39 therapy for ischaemic stroke, showing reduced infarct size and improved BBB integrity when administered 3 hours post-ischaemia.

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.