Sasha A. Singh

This study shows that platelet-derived signals cause distinct endothelial dysfunction in bicuspid aortic valve disease, leading to mitochondrial dysfunction and immune cell recruitment.

This study identifies a distinct circulating extracellular vesicle signature in bicuspid aortic valve disease through single-vesicle analysis and proteomic profiling.

The paper uses proteomic and kinetic analyses to show that APO(a) and APOB in Lp(a) particles have different turnover rates, suggesting a revised model of Lp(a) metabolism.

This study uses multi-omics approaches to analyze human kidney biopsies and identifies complement-mediated cellular dynamics in FSGS progression, highlighting key signaling changes in podocytes and parietal epithelial cells.

This study shows pemafibrate reduces calcific aortic valve disease by modulating macrophage-VIC interactions, independent of lipid lowering.

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

This study uses nanoparticle-enhanced plasma proteomics to identify low-abundant proteins in atherosclerosis-prone mice, revealing disease-related changes in inflammation, lipid metabolism, and potential biomarkers.

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

This paper introduces Pathopticon, a network-based method integrating pharmacogenomics, cheminformatics, and disease phenotypes to prioritize cell lines and drugs for cell type-guided drug discovery.

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.