Jochen Daniel Muehlschlegel

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

Conserved and Divergent Modulation of Calcification in Atherosclerosis and Aortic Valve Disease by Tissue Extracellular Vesicles

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.

Sex differences in gene expression in response to ischemia in the human myocardium

The paper identifies sex-specific gene expression changes in human myocardial tissue after ischemia, highlighting differences in pathways and cell-type proportions between males and females.