Nucleotide-mediated allosteric regulation of bifunctional Rel enzymes
Hedvig Tamman, Katleen Van Nerom, Hiraku Takada, Niels Vandenberk, Daniel Scholl, Yury S. Polikanov, Johan Hofkens, Ariel Talavera, Vasili Hauryliuk, Jelle Hendrix, Abel García-Pino
This study reveals a guanosine-switch mechanism that regulates the opposing activities of bifunctional Rel enzymes through allosteric changes.
bioRxiv · Jun 13, 2019 · PreprintMolecular Biology