Xiangyü Li

Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning

This study identifies PKLR as a therapeutic target for NAFLD and validates two drug candidates through in vitro and in vivo experiments.

A network-based approach reveals the dysregulated transcriptional regulation in non-alcohol fatty liver disease

This study identifies dysregulated transcriptional regulators in NAFLD using network analysis and integrates transcriptomic data with metabolic models.

iNetModels 2.0: an interactive visualization and database of multi-omics data

iNetModels 2.0 provides an interactive platform for visualizing and exploring multi-omics associations in human health and disease.

Discovery of functional alternatively spliced PKM transcripts in human cancers

The paper investigates the prognostic significance of PKM transcripts in 25 cancers and identifies a prognostic signature in KIRC, revealing functional roles of alternatively spliced PKM transcripts.

Classification of clear cell renal cell carcinoma based on PKM alternative splicing

The paper identifies two ccRCC subtypes based on PKM alternative splicing and proposes drug repurposing for each subtype.