Jan Borén

The paper investigates how a disease-associated TSPO variant affects transmembrane helix dynamics using solution NMR spectroscopy.

This study characterizes the effects of reduced phosphatidylcholine synthesis in C. elegans using pcyt-1 mutant alleles, revealing compensatory lipid remodeling and specific developmental vulnerabilities.

This study identifies genetic suppressors of PUFA deficiency in C. elegans, showing that increasing PUFA levels, not stress responses, alleviates the defect.

This study investigates the effects of JNK inhibition on metabolic dysfunction caused by sucrose overconsumption in rats using multi-tissue network analysis.

This study identifies PKLR as a therapeutic target for NAFLD and validates two drug candidates through in vitro and in vivo experiments.

This study identifies dysregulated transcriptional regulators in NAFLD using network analysis and integrates transcriptomic data with metabolic models.

The paper analyzes transcriptomic changes in heart and other metabolically active tissues after myocardial infarction in mice, identifying common and tissue-specific biological responses.

The paper investigates the prognostic significance of PKM transcripts in 25 cancers and identifies a prognostic signature in KIRC, revealing functional roles of alternatively spliced PKM transcripts.

The paper identifies two ccRCC subtypes based on PKM alternative splicing and proposes drug repurposing for each subtype.