Pierre J.J. Mangeol

The paper applies spatial transcriptomics to the adult Drosophila brain and body to map mRNA locations and integrate with single-cell data.

The paper identifies a titin-dependent biomechanical feedback mechanism that adjusts sarcomere structure to meet the functional demands of different insect muscle types.

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

The paper develops a nanobody toolbox to study the localization and dynamics of Drosophila titin homologs in muscle sarcomeres, revealing structural insights and demonstrating nanobodies' utility in vivo.

The paper uses nanobodies and DNA-PAINT to show that Drosophila titin homologs Sallimus and Projectin are staggered in flight muscle sarcomeres.