Jasper Janssens

Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screen

The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.

Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models

The paper identifies synaptic dysfunction in cholinergic projection neurons as an early indicator of Parkinsonism across multiple fly models and links it to olfactory dysfunction and dopaminergic decline.

Spatial transcriptomics in the adult Drosophila brain and body

The paper applies spatial transcriptomics to the adult Drosophila brain and body to map mRNA locations and integrate with single-cell data.

Neuronal identity defines a-synuclein and tau toxicity

The paper identifies molecular signatures of neuronal vulnerability to α-synuclein and tau toxicity, showing differential susceptibility independent of expression levels.

Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes

The paper provides single nucleus and single cell RNA-seq data from Drosophila testes to study spermatogenesis, identifying rare cell types and developmental transitions.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

HyDrop: droplet-based scATAC-seq and scRNA-seq using dissolvable hydrogel beads

HyDrop is a droplet microfluidic platform for scATAC-seq and scRNA-seq that improves throughput and sensitivity while reducing cost.

Decoding gene regulation in the fly brain

The paper identifies regulatory regions and gene regulatory networks in Drosophila brain cell types using chromatin accessibility and transcriptome data.

A single-cell catalogue of regulatory states in the ageing Drosophila brain

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.