Yajie Liang

CountAnywhere provides a smartphone-based tool for accurate and efficient cell counting and viability assessment using hemocytometer images.

The paper introduces FORCENET, an implantable sensor network that maps intercellular forces in living embryos, revealing coordinated mechanical patterns regulated by developmental signaling.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

This paper introduces tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric brain imaging, demonstrating its use in mapping cerebral blood flow, neurovascular coupling, and neuroimmune responses.

OPTRACE improves cell transplantation and tracking in the mouse brain using real-time visualization and longitudinal monitoring to study engraftment dynamics.

This study shows that retinal ganglion cells encode salient visual features in the superior colliculus through their center-surround receptive fields.

This paper develops micro-balloons to control blood flow in mice, enabling real-time in vivo brain imaging during hypoperfusion to study stroke pathophysiology.

This paper develops a multimodal imaging platform to track human cortical organoids in mice after stroke, showing their survival and maturation in specific brain regions.

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

The paper introduces WHaloCaMP, a near-infrared calcium indicator, and demonstrates its use in imaging calcium responses in various organisms.

The paper develops fast and sensitive GCaMP indicators for neural activity imaging, achieving ultra-fast kinetics and high sensitivity.

The paper identifies a distinct population of L6 neurons in mouse V1 that mediate cross-callosal communication through anatomical and functional analysis.

The paper describes engineering eFRET voltage indicators with positive-going fluorescence responses by modifying microbial rhodopsins.

The paper introduces jYCaMP1, a calcium indicator optimized for two-photon imaging at wavelengths above 1000 nm, showing improved performance in mice and flies.

This paper demonstrates ultrafast two-photon fluorescence microscopy for in vivo neural activity imaging at high spatiotemporal resolution in awake mice.

~2-4x SNR gains and 20-300x compression on calcium and voltage imaging, from a patch-wise penalized matrix decomposition that splits signal from temporally uncorrelated noise without hyperparameter tuning.

This paper demonstrates three-photon fluorescence imaging using an axially extended Bessel focus for imaging mouse brain slices and in vivo mouse brain imaging.

This paper introduces a method to achieve video-rate volumetric imaging of brain activity at synaptic resolution using Bessel foci in two-photon microscopy.