Eric Betzig

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

The paper develops photochemical sectioning to enable nanoscale volumetric imaging of whole-mount specimens, demonstrating its application in analyzing axon degeneration and myelination in mouse olfactory bulbs.

The paper introduces PetaKit5D, a software solution for efficient processing of petabyte-scale light sheet microscopy data, achieving performance improvements over existing methods.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

This study investigates how projection neurons in Drosophila establish wiring specificity in the olfactory map through lineage, birth order, and dynamic dendrite remodeling during development.

The paper uses time-lapse imaging in Drosophila to study how olfactory receptor neurons target axons to specific glomeruli, revealing dynamics of branching and bilateral interactions.

This study shows that dendrimer-targeted immunosuppression of microglia accelerates photoreceptor regeneration in zebrafish retinas.

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

The paper tracks progenitor cell movements in zebrafish embryos to uncover coordination mechanisms between neural crest and placode-derived lineages during olfactory neurogenesis.

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.

The paper identifies a pressure relief valve in the endolymphatic sac of zebrafish larvae that regulates inner ear pressure through dynamic lamellar junctions.

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.