Srigokul Upadhyayula

This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.

The paper uses FOC-Map to analyze heterochromatin replication in Drosophila, finding replication foci initially at the PCH domain boundary and later within low-HP1a regions, with CDC45 depletion from the domain.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

The paper develops photochemical sectioning to enable nanoscale volumetric imaging of whole-mount specimens, demonstrating its application in analyzing axon degeneration and myelination in mouse olfactory bulbs.

The paper identifies a conserved meiotic mechanism called virtual nuclear envelope breakdown (vNEBD) in yeast, regulated by Ime2 kinase and Gip1 phosphatase.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

The paper introduces PetaKit5D, a software solution for efficient processing of petabyte-scale light sheet microscopy data, achieving performance improvements over existing methods.

The paper introduces a neural space-time model to recover dynamic scenes in multi-shot computational imaging systems by jointly estimating the scene and its motion, reducing motion artifacts.

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

This study investigates how projection neurons in Drosophila establish wiring specificity in the olfactory map through lineage, birth order, and dynamic dendrite remodeling during development.

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.

The paper identifies a pressure relief valve in the endolymphatic sac of zebrafish larvae that regulates inner ear pressure through dynamic lamellar junctions.

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.