Author

Xiaowen Lyu

Emory UniversityORCID 0000-0002-8317-1141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Amar M. Singh· 1 shared Anne D. DonaldsoniD· 1 shared Daniel A. BartlettiD· 1 shared Danny LeungiD· 1 shared David M. GilbertiD· 1 shared Huimin ZhaoiD· 1 shared Ipek TasaniD· 1 shared Jialiang HuangiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Amar M. Singh

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2 papers

Recent·Most cited

Chrombus-XMBD: A Graph Generative Model Predicting 3D-Genome, ab initio from Chromatin Features

Yuanyuan Zeng, Zhiyu You, Jiayang Guo, Jialin Zhao, Ying Zhou, Jialiang Huang, Xiaowen Lyu, Longbiao Chen, Qiyuan Li

Chrombus-XMBD predicts 3D-genome structures from chromatin features using a graph generative model, outperforming existing methods and showing cross-species generalizability.

bioRxiv · Aug 2, 2023 · PreprintBioinformatics

Replication timing maintains the global epigenetic state in human cells.

Kyle N. Klein, Peiyao A Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A. Bartlett, Amar M. Singh, Ipek Tasan, Meng Zhang, Lotte P. Watts, Shin‐ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Timour Baslan, Danny Leung, Masato T. Kanemaki, , David M. Gilbert

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.

Science · Apr 22, 2021Peer-reviewedMolecular Biology