Lotte P. Watts

The paper shows that p16 expression in ovarian cancers increases sensitivity to CDK2 inhibitors by inhibiting CDK4/6, suggesting p16 as a biomarker for CDK2 inhibitor response.

The paper identifies RIF1-Long as a BRCA1 binding partner that enhances RAD51-dependent repair during DNA replication stress.

This study identifies CDK7-dependent mechanisms regulating RNAPII function at gene 5'- and 3'-ends through biochemical reconstitution and multi-omics analysis.

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.

This study identifies RIF1-Long's role in promoting G1 phase 53BP1 nuclear bodies to protect against replication stress and enhance cell survival.