Author

Shin‐ichiro Hiraga

University of AberdeenORCID 0000-0002-8722-3869Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 5 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Anne D. DonaldsoniD· 5 shared Lotte P. WattsiD· 3 shared Masato T. KanemakiiD· 3 shared Toyoaki NatsumeiD· 2 shared Yuichiro SaitoiD· 2 shared Ali RahjoueiiD· 1 shared Amar M. Singh· 1 shared Antony W. OliveriD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMolecular Biology

Anne D. DonaldsonORCID

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6 papers

Recent·Most cited

Cohesin-axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation

Arrosan Rajalingam, Yusuke Tsuruta, Taniya Roy, Julian Urdiain‐Arraiza, Hasan F Alnaser, Shin‐ichiro Hiraga, Corentin Claeys Bouuaert, Hajime Murakami

This study identifies a conserved Red1 motif that interacts with Rec8 cohesin, promoting DSB formation and Mek1 activation during meiosis.

bioRxiv · Jul 8, 2026 · PreprintMolecular Biology

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P. Watts, Masato T. Kanemaki, Antony W. Oliver, Laurence H. Pearl, Shin‐ichiro Hiraga, Anne D. Donaldson

The paper identifies RIF1-Long as a BRCA1 binding partner that enhances RAD51-dependent repair during DNA replication stress.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

Sandhya Balasubramanian, Matteo Andreani, Júlia Goncalves Andrade, Tannishtha Saha, Devakumar Sundaravinayagam, Javier Garzón, Wenzhu Zhang, Oliver Popp, Shin‐ichiro Hiraga, Ali Rahjouei, Daniel B Rosen, Philipp Mertins, Brian T. Chait, Anne D Donaldson, Michela Di Virgilio

This study identifies phosphorylation of RIF1's intrinsically disordered region as essential for protecting nascent DNA at stalled replication forks during replication stress.

eLife · Mar 31, 2022Peer-reviewedMolecular Biology

Replication timing maintains the global epigenetic state in human cells.

Kyle N. Klein, Peiyao A Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A. Bartlett, Amar M. Singh, Ipek Tasan, Meng Zhang, Lotte P. Watts, Shin‐ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Timour Baslan, Danny Leung, Masato T. Kanemaki, , David M. Gilbert

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.

Science · Apr 22, 2021Peer-reviewedMolecular Biology

RIF1-Long promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Lotte P. Watts, Toyoaki Natsume, Yuichiro Saito, Javier Garzon, Qianqian Dong, Lora Boteva, Nick Gilbert, Masato T. Kanemaki, Shin‐ichiro Hiraga, Anne D. Donaldson

This study identifies RIF1-Long's role in promoting G1 phase 53BP1 nuclear bodies to protect against replication stress and enhance cell survival.

eLife · Nov 3, 2020Peer-reviewedMolecular Biology

Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2

Chandre Monerawela, Shin‐ichiro Hiraga, Anne D. Donaldson

This study identifies that phosphorylation of Rif1 by checkpoint kinases protects nascent DNA from degradation by Sgs1-Dna2 in budding yeast, highlighting a conserved mechanism for genome stability.

bioRxiv · Jun 25, 2020 · PreprintGenetics