Rodolphe Marie

SurpHer: a genetically encoded ratiometric sensor for dynamic extracellular pH imaging

The paper develops SurpHer, a genetically encoded ratiometric pH sensor, and demonstrates its use in imaging extracellular pH dynamics in human cells and tumor microenvironments.

Calibration-free molecular counting from a single DNA-PAINT intensity trace using cumulants

This paper introduces mCOAST, a calibration-free method for accurate molecular counting from DNA-PAINT intensity traces without requiring prior knowledge or extensive post-processing.

In-solution Characterization of Biomolecular Interaction Kinetics under Native Conditions

This paper introduces C-Jump, a method to measure biomolecular interaction kinetics in solution without surface immobilization, demonstrating its accuracy for protein-protein and protein-small molecule interactions.

A microfluidic model to recapitulate pH and oxygen gradients in solid tumors

This paper introduces a microfluidic device that creates oxygen and pH gradients to study their effects on cancer and stromal cells in the tumor microenvironment.

Continuous Titration Based Method For Rapid In-solution Analysis Of Non-covalent Interactions

This paper introduces cSPRING, a method for rapidly measuring binding affinities of protein-small molecule interactions with high accuracy and efficiency.

Sequencing Metrics of Human Genomes Extracted from Single Cancer Cells Individually Isolated in a Valveless Microfluidic Device

This paper describes a valveless microfluidic device for isolating and sequencing single cancer cells, achieving high-quality genome coverage with minimal contamination.