Stine F. Pedersen

SurpHer: a genetically encoded ratiometric sensor for dynamic extracellular pH imaging

The paper develops SurpHer, a genetically encoded ratiometric pH sensor, and demonstrates its use in imaging extracellular pH dynamics in human cells and tumor microenvironments.

NBCn1 interacts with DYNLL1 and regulates ciliary length and SUFU localization to control Sonic hedgehog signaling

This paper identifies NBCn1 as a ciliary membrane component that regulates ciliary length and Sonic hedgehog signaling through interactions with DYNLL1 and SUFU.

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminus

The paper presents the cryo-EM structure of HsNHE6, revealing its dimeric architecture, ion-binding site, and lipid-stabilized gate, along with insights into its disordered C-terminus and functional roles in ion exchange and disease.

A microfluidic model to recapitulate pH and oxygen gradients in solid tumors

This paper introduces a microfluidic device that creates oxygen and pH gradients to study their effects on cancer and stromal cells in the tumor microenvironment.

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis

This study shows that acidic tumor environments enhance pancreatic cancer stem cell properties and metastasis in mice.