Mirko Brüggemann

The paper uses kinetic modeling and statistical learning to quantify how mutations affect splicing outcomes, revealing context-dependent isoform changes and cryptic splice site activation.

This study uses long-read transcriptome sequencing to analyze SF3B1 mutations in CLL and MDS patients, revealing common splicing alterations and their impact on disease prognosis.

This study shows that Makorin1 promotes oskar translation by displacing Bruno from its 3' UTR, essential for embryonic patterning and germ cell formation in Drosophila.

This study identifies MKRN1 as a key player in ribosome-associated quality control by promoting ribosome stalling at poly(A) sequences to prevent erroneous protein production.