Author

Daniel B. Mihaylov

MRC Laboratory of Molecular BiologyORCID 0000-0002-8375-3360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexandru Radu AricescuiD· 2 shared Abhay KotechaiD· 1 shared Basil J. GreberiD· 1 shared Benjamin BasantaiD· 1 shared Claudio F. GrosmaniD· 1 shared Dimple KariaiD· 1 shared Fujiet KohiD· 1 shared Gabriel C. LanderiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Alexandru Radu AricescuORCID

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2 papers

Recent·Most cited

GABAA receptor gating imaged on the millisecond timescale

Daniel B. Mihaylov, Tomas Malinauskas, Gisela D. Cymes, Jonas Miehling, Veronica T.-C. Chang, Katerina Naydenova, Claudio F. Grosman, Alexandru Radu Aricescu

Single-particle cryo-EM was used to explore the dynamic conformational landscape of three human GABAA receptor variants within the first 10 milliseconds of interaction with their neurotransmitter agonists.

bioRxiv · Sep 29, 2025 · PreprintNeuroscience

Sub-3 A resolution protein structure determination by single-particle cryo-EM at 100 keV

Dimple Karia, Fujiet Koh, Wen Yang, Victoria I. Cushing, Benjamin Basanta, Daniel B. Mihaylov, Sagar Khavnekar, Ondřej Vyroubal, Miloš Malínský, Ondřej Sháněl, Vojtěch Doležal, Jürgen M. Plitzko, Lingbo Yu, Gabriel C. Lander, Alexandru Radu Aricescu, , Abhay Kotecha

This paper demonstrates that a 100 keV cryo-TEM with advanced components can achieve sub-3 Å resolution structures of various proteins and viruses.

Structure · Jul 30, 2025Peer-reviewedBiophysics