Author

Dimple Karia

Thermo Fisher Scientific (Netherlands)ORCID 0000-0002-3776-1650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:cryo-EM· 1 Assay:electronic health records· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Abhay KotechaiD· 2 shared Alexandru Radu AricescuiD· 1 shared Amrita RaiiD· 1 shared Basil J. GreberiD· 1 shared Benjamin BasantaiD· 1 shared Christopher ThompsoniD· 1 shared Daniel B. MihayloviD· 1 shared Fujiet KohiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Abhay KotechaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Depth-resolved analysis reveals target-dependent cryo-FIB damage profiles

Robert M. Nwokonko, M. Zuhaib Qayyum, Dimple Karia, Vishal Maingi, Amrita Rai, Yuewen Sheng, Syed Asfarul Haque, Christopher Thompson, Sanja Sviben, Haruaki Yanagisawa, José Miguel de la Rosa-Trevin, Ravi Kalathur, Georgios Skiniotis, Abhay Kotecha

The paper analyzes depth-dependent structural damage caused by cryo-FIB milling using apoferritin as a reporter, showing damage varies with ion type and molecular target.

bioRxiv · Sep 18, 2026 · PreprintMolecular Biology

Sub-3 A resolution protein structure determination by single-particle cryo-EM at 100 keV

Dimple Karia, Fujiet Koh, Wen Yang, Victoria I. Cushing, Benjamin Basanta, Daniel B. Mihaylov, Sagar Khavnekar, Ondřej Vyroubal, Miloš Malínský, Ondřej Sháněl, Vojtěch Doležal, Jürgen M. Plitzko, Lingbo Yu, Gabriel C. Lander, Alexandru Radu Aricescu, , Abhay Kotecha

This paper demonstrates that a 100 keV cryo-TEM with advanced components can achieve sub-3 Å resolution structures of various proteins and viruses.

Structure · Jul 30, 2025Peer-reviewedBiophysics