Denis A. Evseenko

This study identifies NCAM1 as a regulator of regenerative competence in adult skin wounds through single-cell RNA sequencing and functional analysis.

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

This study shows that gp130-Y814 signaling is critical for dynamin-mediated endocytosis, MAPK/p38 activation, and chronic inflammation persistence in high-fat diet models.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

This study examines DNA methylation changes in human chondrocytes across ontogeny and develops an epigenetic clock showing STAT3 agonist reduces epigenetic age in aged chondrocytes.

This study identifies a gp130 signaling module that enhances tissue regeneration and prevents pathological outcomes by modulating cellular stress responses.