Qi-Long Ying

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

This paper shows that selective GSK3 inhibition with BRD0705 supports self-renewal of mouse stem cells and enables co-culture of naive and primed stem cells while preserving their identities.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.