The AID2 system offers a potent tool for rapid, reversible, or sustained degradation of essential proteins in live mice
Valentina C. Sladky, Margaret A. Strong, Daniel Tapias-Gomez, Cayla E Jewett, Chelsea G Drown, Phillip M. Scott, Andrew Jon Holland
The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.
Science Advances · Feb 28, 2025Peer-reviewedCell Biology