Author

Valentina C. Sladky

Innsbruck Medical UniversityORCID 0000-0002-2973-3174Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Andreas VillungeriD· 3 shared Felix EichiniD· 3 shared Marina LeoneiD· 2 shared Thomas KolbeiD· 2 shared André F. RendeiroiD· 1 shared Andrew Jon HollandiD· 1 shared C. Manzl· 1 shared Cayla E JewettiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

Andreas VillungerORCID

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Author profile →

4 papers

Recent·Most cited

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

Marina Leone, Nadine Kinz, Felix Eichin, D. Obwegs, Valentina C. Sladky, Vincent Z. Braun, R. Hirschberger, Dario Rizzotto, L. Englmaier, C. Manzl, Katharina Moos, Julia Mergner, Piero Giansanti, Nicole Martínez‐García, Margarita M. Marqués, , Andreas Villunger

This study shows the PIDDosome restricts cardiomyocyte polyploidization during postnatal heart development through p21/Cdkn1a, independent of p53.

Cell Death and Differentiation · Jan 12, 2026Peer-reviewedDevelopmental Biology

tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals

Lukas Englmaier, Marta Walczak, Daniel Malzl, Cristián Eggers, Felix Eichin, Valentina C. Sladky, Filip Gallob, Yevheniia Tyshchenko, Zarghun Zarif, Thomas Kolbe, Lama AlAbdi, Jörg Menche, Nathalie Spassky, Stephan Geley, Walter Rossmanith, , Andreas Villunger

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

bioRxiv · Oct 24, 2025 · PreprintCell Biology

Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart

Felix Eichin, Valentina C. Sladky, Matthäus A. Reiner, Marina Leone, Ernesto Abila, André F. Rendeiro, Ralph Thomas Böttcher, Maik Dahlhoff, Thomas Kolbe, Andreas Villunger

This study shows that sequential auto-processing of PIDD1 is essential for controlling ploidy in liver and heart development, with distinct roles for caspase-2 in different cell types.

bioRxiv · Jun 23, 2025 · PreprintCell Biology

The AID2 system offers a potent tool for rapid, reversible, or sustained degradation of essential proteins in live mice

Valentina C. Sladky, Margaret A. Strong, Daniel Tapias-Gomez, Cayla E Jewett, Chelsea G Drown, Phillip M. Scott, Andrew Jon Holland

The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.

Science Advances · Feb 28, 2025Peer-reviewedCell Biology